Table 3 CTL Epitopes shortlisted for Vaccine construction
From: In-silico design of an immunoinformatics based multi-epitope vaccine against Leishmania donovani
Sl No | Protein ID | Allele supertype | Epitopes | Vaxijen score | Binding alleles # | IEDB Immunogenicity Score |
|---|---|---|---|---|---|---|
1 | XP_003863163 | A1 | MTTIRCLSY | 0.503 | HLA*A0101,HLA*B5801, HLA*B3501, HLA*B1501 | 0.040 |
A2 | IMIAITVVL | 0.842 | HLA-A0201, HLA*A0202, HLA*A0211, HLA*A0212, HLA*B3901, HLA*B1501 HLA*A0203, HLA*A0206, HLA*A0216, HLA*A0217, HLA*A0219, HLA*B5801 HLA*B3501 | 0.307 | ||
A3 | MSYAVEATK | 0.592 | HLA*A0301, HLA*B5801 | 0.228 | ||
B7 | LPMAADTPA | 0.635 | HLA*B0702, HLA*B3501, HLA*B3503 | 0.067 | ||
2 | XP_003865788 | A2 | FQDDYFYPV | 1.756 | HLA*A0201 HLA*A0202 HLA*A0203 HLA*A0205 HLA*A0206 HLA*A0207 HLA*A0211 HLA*A0212 HLA*A0216 HLA*A0217 HLA*A0219 HLA*A0250 HLA*B2720 HLA*B3901, HLA*A0101, HLA*B3503 | 0.126 |
A3 | RLIRGNPVK | 1.453 | HLA*A0301 | 0.136 | ||
B7 | RPPFAVTIF | 1.475 | HLA*B0702, HLA*B5802, HLA*B3501, HLA*B3503 | 0.301 | ||
3 | XP_003857936 | A1 | FSAAYYGRF | 1.964 | HLA*A0101,HLA*B3503, HLA*B3501,HLA*B5801, HLA*B1501 | 0.103 |
A2 | RVMRYGFSV | 0.595 | HLA*A0201, HLA*B2720, HLA*A0206, HLA*A0205, HLA*B0702, HLA*A0250, HLA*A0219, HLA*A0217, HLA*A0216, HLA*A0212, HLA*A0211, HLA*A0207, HLA*A0203, HLA*A0202, HLA*B5801 | 0.025 | ||
A3 | MLYNNFTLA | 0.694 | HLA*A0201, HLA*A0202, HLA*A0203, HLA*A0206, HLA*A0250, HLA*A0211, HLA*A0212, HLA*A0216, HLA*A0219, HLA*A0301 | 0.122 | ||
4 | XP_003864424 | B7 | SPWLSPIPH | 2.064 | HLA*B3501, HLA*B0702 | -0.004 |