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Fig. 4 | BMC Bioinformatics

Fig. 4

From: Constrained Fourier estimation of short-term time-series gene expression data reduces noise and improves clustering and gene regulatory network predictions

Fig. 4

Post-processing with NCA performs better when data was treated with NR. A When reconstructed 10 transcription factor (TF) signals from 3 replicates of data, the correlation between the replicates was always higher when the data was first treated with our constrained Fourier estimation. Here we show noise variance \(\sigma ^2=0.3\). Other variances and the GNCA-r are shown is Additional file 1: Fig. S5. Numbers besides column are the correlation of 3 replicates from treated data. B, C GNCA-r reconstructed the 3 replicates from the pre-treated (solid) data significantly better (\(p<10^{-10}\)) than the noisy data (dashed). Here we show temporal reconstruction of two arbitrary TFs

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BMC Bioinformatics

ISSN: 1471-2105

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