Fig. 5
From: SMaSH: a scalable, general marker gene identification framework for single-cell RNA-sequencing
Marker genes for the mouse brain cell sub-types from the Inhibitory neuron broad types, and human foetal organ of origin classification. The mean logarithm of gene expression for mouse brain cell Inhibitory neuron cell sub-type markers. A the markers for scGeneFit; B the markers for RankCorr; C markers from SMaSH’s network mode. Particularly in the case of SMaSH unique patterns can still be identified in this highly granular cell-type identification problem, whereas approaches such as scGeneFit are not able to identify many markers which uniquely resolve the sub-types present. D SMaSH is able to select statistically significant markers for a highly imbalanced problem of distinguishing organs of origin in foetal scRNA-seq