Fig. 1
From: SEMgsa: topology-based pathway enrichment analysis with structural equation models
Visualisation of SEMgsa() procedure starting from Asthma KEGG pathway. The first graph summarise Asthma network properties, showing a pathway consisting of 31 nodes, 4 edges and 25 singletons. To maximise pathway information, SEMgsa procedure adds a binary group node (G = {0, 1}) that directly affects the set of genes in the pathway. In this way, the pathway with numerous singleton genes is edged with a group node and group-genes, resulting in a linked graph