Table 4 Benchmark results on Coronavirus disease (COVID-19) and frontotemporal dementia (FTD)
From: SEMgsa: topology-based pathway enrichment analysis with structural equation models
Metrics | Method | Disease | |
|---|---|---|---|
Coronavirus disease (COVID-19) | Frontotemporal dementia (FTD)* | ||
Sensitivity | SEMgsa() | \(< {\textbf {0.001}}\) | \(< {\textbf {0.001}}\) |
DEGraph | 0.771 | 0.653 | |
NetGSA | 0.011 | 0.563 | |
ORA | 0.709 | 0.375 | |
PathwayExpress | 0.444 | 0.981 | |
TopologyGSA | \(< 0.001\) | 0.740 | |
Prioritization | SEMgsa() | 10 | 39 |
DEGraph | 90 | 39 | |
NetGSA | 63 | 44 | |
ORA | 83 | 56 | |
PathwayExpress | 32 | 100 | |
TopologyGSA | 13 | 58 | |