Fig. 4

Differential Methylation Analysis in Arboleda-Tham Syndrome. A Hilbert curve of CpGs from chr17, outlined is the region corresponding to Chr17:46.59–46.73 Mb, the HOXB cluster. CpGs with FDR < 0.1 are highlighted red. Point size is scaled to maximum significance value. B Chr17:46.59–46.73 Mb. HOXB cluster. GVIZ track stack plot. Top track shows mean β value per group, next track shows Δβ, where Δβ = β_Control−β_{Arboleda-Tham}. Below the gene model track is the DMR track, highlighting the regions called as a DMR at each result layer from DMRscaler and from each competing method. C Chr2:81.5–84.5 Mb. Design same as 4A. D Chr2:81.5–84.5 Mb. Tracks same as 4B