Fig. 1
From: Small molecule modulation of microbiota: a systems pharmacology perspective
Illustration of relationships between microbiomes. (A) Microbe A and B compete for metabolite a and has a negative effect on each other. This negative relationship is shown with a red arrow. Microbe A and microbe C have a cross-feeding relationship. Microbe A can degrade macromolecule a into metabolite c, which can be taken by microbe C. Cross-feedings also exist between microbe B and C, and between microbe B and D through metabolite c and d, respectively. (B) An example for the calculation of the relationship between two microbes. Negative effects are calculated as the Jaccard similarity between microbe’s consumption profiles. The positive effect is calculated as the Jaccard similarity of one microbe's consumption profile and another's production profile. The final effect is the aggregation of the negative effect and the positive effect