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Table 1 Pareto MTL versus scalarization

From: Trade-off between conservation of biological variation and batch effect removal in deep generative modeling for single-cell transcriptomics

Dataset

Percentage

Hypervolume

NDC

Train

Test

Train

Test

Train

Test

Pareto MTL

Scalarization

Pareto MTL

Scalarization

Pareto MTL

Scalarization

Pareto MTL

Scalarization

Pareto MTL

Scalarization

Pareto MTL

Scalarization

\({\overline{U}}_n(\varvec{\phi }, \varvec{\theta })\) versus \({\overline{V}}_n(\varvec{\phi })\) when \(V_n(\varvec{\phi }) = MINE(\varvec{\phi })\)

TM-MARROW

\(\varvec{0.88} \pm 0.08\)

\(0.57 \pm 0.17\)

\(\varvec{0.58} \pm 0.16\)

\(0.42 \pm 0.15\)

\(0.19 \pm 0.01\)

\(0.19 \pm 0.01\)

\(0.13 \pm 0.03\)

\(0.13 \pm 0.04\)

\(\varvec{8.1} \pm 1.20\)

\(3.0 \pm 0.47\)

\(\varvec{5.8} \pm 1.55\)

\(2.5 \pm 0.71\)

MACAQUE-RETINA

\(\varvec{0.83} \pm 0.10\)

\(0.46 \pm 0.09\)

\(\varvec{0.47} \pm 0.13\)

\(0.35 \pm 0.13\)

\(\varvec{0.51} \pm 0.01\)

\(0.50 \pm 0.01\)

\(0.35 \pm 0.02\)

\(0.35 \pm 0.02\)

\(\varvec{7.5} \pm 1.27\)

\(3.7 \pm 0.95\)

\(\varvec{4.2} \pm 1.03\)

\(2.3 \pm 1.06\)

\({\overline{U}}_n(\varvec{\phi },\varvec{\theta })\) versus \({\overline{V}}_n(\varvec{\phi })\) when \(V_n(\varvec{\phi })=MMD(\varvec{\phi })\)

TM-MARROW

\(\varvec{0.84} \pm 0.06\)

\(0.58 \pm 0.06\)

\(\varvec{0.55} \pm 0.08\)

\(0.49 \pm 0.07\)

\(26.68 \pm 0.41\)

\(\varvec{26.91} \pm 0.37\)

\(25.95 \pm 1.32\)

\(\varvec{26.78} \pm 1.03\)

\(\varvec{8.4} \pm 0.70\)

\(6.6 \pm 0.70\)

\(\varvec{5.8} \pm 1.03\)

\(5.3 \pm 0.82\)

MACAQUE-RETINA

\(\varvec{0.78} \pm 0.10\)

\(0.75 \pm 0.10\)

\(\varvec{0.61} \pm 0.09\)

\(0.55 \pm 0.06\)

\(752.35 \pm 17.90\)

\(\varvec{755.46} \pm 6.19\)

\(623.00 \pm 83.73\)

\(\varvec{700.07} \pm 32.06\)

\(\varvec{8.0} \pm 0.47\)

\(6.9 \pm 1.10\)

\(\varvec{6.0} \pm 0.94\)

\(4.7 \pm 0.82\)

  1. Higher percentage/hypervolume/NDC indicates  of better Pareto front estimation
  2. The values are mean ± standard deviation over 10 Monte Carlos of training-testing split of the dataset. Bold illustrates higher mean in comparison