Fig. 10
From: GMMchi: gene expression clustering using Gaussian mixture modeling
Schematic of the probe combining pipeline: a the pipeline for probe combining is used to combine probe sets in microarray data that represent the same gene while keeping together probe sets with a different expression patterns as potential splice variants. b Total distribution of the r-values for all pairs of probe sets of the same gene. We apply GMMchi to the bimodal distribution which shows the difference between pairs of probes that are associated with each other, at the upper end, and those that are not, the lower distribution. The cutoff that defines the lower r threshold value for probes that are significantly associated with each other is at 0.69, where the two fitted distributions intersect, as indicated by the vertical red dotted line