Fig. 5
From: iDMET: network-based approach for integrating differential analysis of cancer metabolomics
Assessment of connection between P17-1 and P24-1 in the network. a Venn diagram showing the number of metabolites common to both of the two cohort studies on which P17-1 [37] and P24-1 [44] were based. In both studies, metabolomic analyses were conducted on human clear cell renal cell carcinoma and normal kidney tissue using GC–MS and LC–MS. b Comparison of changes in the level of metabolites in node P17-1 versus node P24-1 (r = 0.808, p < 0.001, Spearman’s rank test). In both nodes, the changes from normal tissue to tumor were calculated. Red plots represent metabolites found to be upregulated in the tumor group, whereas blue plots represent those found to be downregulated. c A 2 × 2 contingency table of the numbers of upregulated and downregulated metabolites in the two nodes (log2 odds ratio = 8.95, p-value = 4.2 × 10−32). The table was created based on (b). See Fig. 2 for details on the table creation