Fig. 4

Genes for which interaction with treatment is identified, by the different methods, in at least 20% of 500 replications of the training set (representing 60% of the randomized clinical trial of breast cancer) for distant-recurrence free survival. Each square represents a gene whose the interaction with treatment is selected according to the cut-off. The intensity of the color is proportional to the percentage that a model with a gene-treatment interaction and its main effect is selected among all models selecting this gene-treatment interaction term. This allows to characterise the property of the hierarchical interaction constraint