Table 1 Correlation between XRCC4 and relate genes and markers of immune cells analyzed by TIMER
Description | Gene markers | PRAD | THCA | ||||
|---|---|---|---|---|---|---|---|
Cor | P | adj.p | Cor | P | adj.p | ||
CD8 + T cell | CD8A | 0.308 | *** | *** | 0.127 | 0.004 | 0.017 |
| Â | CD8B | 0.320 | *** | *** | 0.219 | *** | *** |
T cell (general) | CD3D | 0.297 | *** | *** | 0.210 | *** | *** |
| Â | CD3E | 0.302 | *** | *** | 0.205 | *** | *** |
| Â | CD2 | 0.334 | *** | *** | 0.231 | *** | *** |
B cell | CD19 | 0.242 | *** | *** | 0.175 | *** | 0.002 |
| Â | CD79A | 0.251 | *** | *** | 0.196 | *** | *** |
Monocyte | CD86 | 0.319 | *** | *** | 0.315 | *** | *** |
| Â | CD115 (CSF1R) | 0.325 | *** | *** | 0.259 | *** | *** |
TAM | CCL2 | 0.204 | *** | *** | 0.260 | *** | *** |
| Â | CD68 | 0.239 | *** | *** | 0.324 | *** | *** |
| Â | IL10 | 0.246 | *** | *** | 0.279 | *** | *** |
M1 Macrophage | INOS (NOS2) | 0.198 | *** | *** | 0.190 | *** | *** |
| Â | IRF5 | 0.192 | *** | *** | 0.354 | *** | *** |
| Â | COX2(PTGS2) | 0.318 | *** | *** | 0.378 | *** | *** |
M2 Macrophage | CD163 | 0.260 | *** | *** | 0.315 | *** | *** |
| Â | VSIG4 | 0.262 | *** | *** | 0.271 | *** | *** |
| Â | MS4A4A | 0.234 | *** | *** | 0.303 | *** | *** |
Neutrophils | CD66b (CEACAM8) | 0.019 | 0.667 | 0.813 | 0.232 | *** | *** |
| Â | CD11b (ITGAM) | 0.349 | *** | *** | 0.281 | *** | *** |
| Â | CCR7 | 0.303 | *** | *** | 0.259 | *** | *** |
Natural killer cell | KIR2DL1 | 0.030 | 0.499 | 0.798 | − 0.056 | 0.205 | 0.548 |
|  | KIR2DL3 | 0.033 | 0.461 | 0.753 | − 0.009 | 0.836 | 0.904 |
|  | KIR2DL4 | 0.185 | *** | *** | − 0.034 | 0.442 | 0.630 |
|  | KIR3DL1 | 0.122 | 0.007 | 0.115 | − 0.004 | 0.933 | 0.956 |
| Â | KIR3DL2 | 0.167 | *** | 0.004 | 0.077 | 0.081 | 0.360 |
|  | KIR3DL3 | -0.028 | 0.529 | 0.705 | − 0.036 | 0.413 | 0.705 |
|  | KIR2DS4 | 0.083 | 0.065 | 0.434 | − 0.029 | 0.520 | 0.774 |
Dendritic cell | HLA-DPB1 | 0.284 | *** | *** | 0.244 | *** | *** |
| Â | HLA-DQB1 | 0.250 | *** | *** | 0.157 | *** | 0.004 |
| Â | HLA-DRA | 0.349 | *** | *** | 0.299 | *** | *** |
| Â | HLA-DPA1 | 0.335 | *** | *** | 0.255 | *** | *** |
| Â | BDCA-1(CD1C) | 0.402 | *** | *** | 0.366 | *** | *** |
| Â | BDCA-4(NRP1) | 0.216 | *** | *** | 0.170 | *** | *** |
| Â | CD11c (ITGAX) | 0.211 | *** | *** | 0.231 | *** | *** |
Th1 | T-bet (TBX21) | 0.247 | *** | *** | 0.090 | 0.041 | 0.138 |
| Â | STAT4 | 0.341 | *** | *** | 0.304 | *** | *** |
| Â | STAT1 | 0.352 | *** | *** | 0.425 | *** | *** |
|  | IFN-γ (IFNG) | 0.228 | *** | *** | 0.149 | 0.001 | 0.003 |
| Â | IL12A | 0.237 | *** | *** | 0.151 | 0.001 | 0.002 |
| Â | IL12B | 0.291 | *** | *** | 0.264 | *** | *** |
Th2 | GATA3 | 0.312 | *** | *** | 0.335 | *** | *** |
| Â | STAT6 | 0.245 | *** | *** | 0.299 | *** | *** |
| Â | STAT5A | 0.331 | *** | *** | 0.300 | *** | *** |
|  | IL13 | − 0.012 | 0.782 | 0.845 | 0.059 | 0.183 | 0.519 |
Treg | FOXP3 | 0.215 | *** | *** | 0.314 | *** | *** |
| Â | CCR8 | 0.336 | *** | *** | 0.318 | *** | *** |
| Â | STAT5B | 0.378 | *** | *** | 0.194 | *** | *** |
|  | TGFβ (TGFB1) | 0.229 | *** | *** | 0.180 | *** | *** |