Fig. 4

The immune astrocyte module corresponds to the A1 neurotoxic phenotype. (a) Overlap analysis between modules from EAE/wildtype networks and the reactive astrocyte transcripts used in Liddelow et al. [13]. The only network enriched for reactive astrocyte transcripts across all disease and wildtype modules is dM15. (b) Left heatmap shows the Pearson correlation between reactive astrocyte transcripts in the EAE astrocyte samples from Itoh et al. [8]. Middle heatmap shows the Pearson correlation between reactive astrocyte transcripts in the wildtype astrocyte samples from Itoh et al. [8]. Right heatmap shows the differential co-expression of reactive astrocyte transcripts between EAE and wildtype conditions, where high z-scores represent higher co-expression in EAE. Boxes around heatmap cells signify significantly different correlations (FDR < 0.05). Right boxplots show the quantification of the Pearson correlations from the first two heatmaps