iIL13Pred: improved prediction of IL-13 inducing peptides using popular machine learning classifiers

BMC Bioinformatics

Table 4 Case study 2: potential IL-13 inducing peptides from SARS-CoV-2 wild-type and mutated spike protein

SARS-CoV-2 variants	Mutation	Reference peptide	Mutated peptide	Score_R (probability)		Score_M (probability)
SARS-CoV-2 variants	Mutation	Reference peptide	Mutated peptide	Proposed study	Jain et al. [19]	Proposed study	Jain et al. [19]
Alpha (B.1.1.7)	A570D	NKKFLPFQQFGRDIA	NKKFLPFQQFGRDID	0.03	0.05	0.04	0.11
	A570D	KFLPFQQFGRDIADT	KFLPFQQFGRDIDDT	0.04	0.03	0.03	0.06
	T716I	SNNSIAIPTNFTISV	SNNSIAIPINFTISV	0.01	0.04	0.07	0.06
	S980A	NFGAISSVLNDILSR	NFGAISSVLNDILAR	0.02	0.04	0.02	0.06
		GAISSVLNDILSRLD	GAISSVLNDILARLD	0.04	0.03	0.06	0.08
		VLNDILSRLDKVEAE	VLNDILARLDKVEAE	0.07	0.03	0.04	0.07
		LNDILSRLDKVEAEV	LNDILARLDKVEAEV	0.07	0.05	0.04	0.08
		NDILSRLDKVEAEVQ	NDILARLDKVEAEVQ	0.05	0.04	0.05	0.09
	D1118H	TQRNFYEPQIITTDN	TQRNFYEPQIITTHN	0.01	0.06	0.01	0.04
		QRNFYEPQIITTDNT	QRNFYEPQIITTHNT	0.01	0.07	0.01	0.03
		YEPQIITTDNTFVSG	YEPQIITTHNTFVSG	0.01	0.04	0.01	0.06
Beta (B.1.351)	L18F	LVLLPLVSSQCVNLT	LVLLPLVSSQCVNFT	0.05	0.06	0.05	0.04
	L18F	LLPLVSSQCVNLTTR	LLPLVSSQCVNFTTR	0.01	0.07	0.01	0.02
	D80A	VSGTNGTKRFDNPVL	VSGTNGTKRFANPVL	0.01	0.05	0.01	0.12
		GTNGTKRFDNPVLPF	GTNGTKRFANPVLPF	0.01	0.02	0.01	0.07
		SGTNGTKRFDNPVLP	SGTNGTKRFANPVLP	0.01	0.09	0.01	0.02
Delta (B.1.617.2	T19R	LVLLPLVSSQCVNLT	LVLLPLVSSQCVNLR	0.05	0.06	0.04	0.04
	R158G	FRVYSSANNCTFEYV	FGVYSSANNCTFEYV	0.02	0.03	0.02	0.06
	P618R	TQTNSPRRARSVASQ	TQTNSRRRARSVASQ	0.01	0.02	0.02	0.08
	P618R	QTNSPRRARSVASQS	QTNSRRRARSVASQS	0.02	0.02	0.02	0.08
	D950N	DSLSSTASALGKLQD	DSLSSTASALGKLQN	0.05	0.05	0.04	0.06

ISSN: 1471-2105