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Fig. 2 | BMC Bioinformatics

Fig. 2

From: DNAfusion: an R/Bioconductor package for increased sensitivity of detecting gene fusions in liquid biopsies

Fig. 2

Comparing DNAfusion with AVENIO in the training cohort. a Number of EML4 clipped reads determined with DNAfusion in cell lines. b Number of patients with detectable and undetectable EML4-ALK in liquid biopsies, determined with either AVENIO or DNAfusion (n = 41). c Number of patients who are EML4-ALK positive or negative determined with DNAfusion in patients who are EML4-ALK negative with AVENIO. Patients are grouped according to their ctDNA status apart from EML4-ALK as determined with AVENIO. d The EML4 breakpoint read depth in patients positive for EML4-ALK in both AVENIO and DNAfusion (n = 15) or only DNAfusion (n = 10). Median and IQR are indicated. e Number of healthy individuals with detectable or undetectable EML4-ALK in plasma, determined with either AVENIO or DNAfusion (n = 7). f Number of positive droplets for EML4-ALK in patients identified as EML4-ALK positive with DNAfusion but not with AVENIO. *P < 0.05

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BMC Bioinformatics

ISSN: 1471-2105

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