Table 10 Block model simulation results: 2500 phenotype 0, 2500 phenotype 1 subjects
From: Automatic block-wise genotype-phenotype association detection based on hidden Markov model
Method | Sensitivity | Specificity | MCC |
|---|---|---|---|
HMM 0.1 | 0.6706 | 0.9907 | 0.6402 (0.3950) |
HMM 0.15 | 0.7492 | 0.9957 | 0.7510 (0.3184) |
HMM 0.2 | 0.8117 | 0.9958 | 0.8139 (0.2441) |
Bonferroni | 0.0789 | 1.0000 | 0.2496 (0.1079) |
FDR | 0.4308 | 0.9831 | 0.4545 (0.1158) |
SKAT | 0.8103 | 0.9716 | 0.6705 (0.2533) |
SKATO | 0.7347 | 0.9899 | 0.7171 (0.2436) |
Burden | 0.6946 | 0.9920 | 0.6996 (0.2455) |
wtest | 0.7099 | 0.9902 | 0.6933 (0.2460) |