Table 2 HMM model simulation results. 1000 phenotype 0, 1000 phenotype 1 subjects
From: Automatic block-wise genotype-phenotype association detection based on hidden Markov model
Method | Sensitivity | Specificity | MCC |
|---|---|---|---|
HMM 0.1 | 0.9945 | 0.9950 | 0.9598 (0.0373) |
HMM 0.15 | 0.9849 | 0.9981 | 0.9712 (0.0327) |
HMM 0.2 | 0.9420 | 0.9977 | 0.9409 (0.0764) |
Bonferroni | 0.4679 | 0.9999 | 0.6215 (0.2432) |
FDR | 0.8040 | 0.9748 | 0.6877 (0.1875) |
SKAT | 0.2009 | 0.9941 | 0.3676 (0.1458) |
SKATO | 0.3099 | 0.9861 | 0.4610 (0.1715) |
burden | 0.3023 | 0.9872 | 0.4493 (0.1928) |
wtest | 0.8688 | 0.9710 | 0.8163 (0.1850) |