Table 3 Block model simulation results: 1000 phenotype 0, 1000 phenotype 1 subjects
From: Automatic block-wise genotype-phenotype association detection based on hidden Markov model
Method | Sensitivity | Specificity | MCC |
|---|---|---|---|
HMM 0.1 | 0.8543 | 0.9926 | 0.8700 (0.1282) |
HMM 0.15 | 0.7936 | 0.9958 | 0.8469 (0.1327) |
HMM 0.2 | 0.6739 | 0.9965 | 0.7719 (0.1427) |
Bonferroni | 0.0173 | 0.9999 | 0.0886 (0.0927) |
FDR | 0.2546 | 0.9816 | 0.3074 (0.0610) |
SKAT | 0.7456 | 0.9019 | 0.5649 (0.3174) |
SKATO | 0.6672 | 0.9383 | 0.5754 (0.2924) |
Burden | 0.6090 | 0.9572 | 0.6111 (0.3048) |
wtest | 0.6034 | 0.9609 | 0.6356 (0.2558) |