Table 6 Block model simulation results: 1500 phenotype 0, 500 phenotype 1 subjects
From: Automatic block-wise genotype-phenotype association detection based on hidden Markov model
Method | Sensitivity | Specificity | MCC |
|---|---|---|---|
HMM 0.1 | 0.8960 | 0.9949 | 0.9018 (0.1115) |
HMM 0.15 | 0.9087 | 0.9943 | 0.9082 (0.0797) |
HMM 0.2 | 0.9135 | 0.9949 | 0.9211 (0.0640) |
Bonferroni | 0.1861 | 1.000 | 0.3980 (0.1320) |
FDR | 0.3867 | 0.9798 | 0.4292 (0.0717) |
SKAT | 0.5342 | 0.9380 | 0.4820 (0.2129) |
SKATO | 0.5789 | 0.9499 | 0.5852 (0.2017) |
Burden | 0.4931 | 0.9712 | 0.5866 (0.1822) |
wtest | 0.6692 | 0.9597 | 0.6812 (0.2358) |