Fig. 1
From: A mixed-effects stochastic model reveals clonal dominance in gene therapy safety studies
Schematic representation of the analysis: A three-dimensional clonal tracking dataset (left) is received as input from our proposed stochastic framework RestoreNet (middle). It mainly consists in two parts, such as a maximum likelihood step to infer the base LLA model, and an expectation-maximization step to infer the random-effects LLA formulation. Finally, a clonal piechart is returned, where each clone is identified by a pie whose slices are lineage specific and proportional to their expansion rates (right)