Table 2 Conditional expectations \(E_{\pmb {u}\vert \Delta \pmb {y}; \hat{\pmb {\psi }}}[\pmb {u}]\) of the random-effects obtained from the estimated parameters \(\hat{\pmb {\psi }}\) for each reaction rate (rows) under different magnitudes of the noice variance \(\sigma ^2\) (outer columns) for each clone (inner columns)
From: A mixed-effects stochastic model reveals clonal dominance in gene therapy safety studies
\(\sigma ^2 = 0.1\) | \(\sigma ^2 = 1\) | \(\sigma ^2 = 10\) | |||||||
|---|---|---|---|---|---|---|---|---|---|
\(c_1\) | \(c_2\) | \(c_3\) | \(c_1\) | \(c_2\) | \(c_3\) | \(c_1\) | \(c_2\) | \(c_3\) | |
\(\alpha _{A}\) | 0.198 | 0.198 | 0.199 | 0.183 | 0.191 | 0.198 | 0.151 | 0.139 | 0.127 |
\(\alpha _{B}\) | 0.151 | 0.152 | 0.148 | 0.146 | 0.148 | 0.145 | 0.163 | 0.148 | 0.137 |
\(\alpha _{C}\) | 0.171 | 0.168 | 0.509 | 0.163 | 0.168 | 0.518 | 0.166 | 0.175 | 0.649 |
\(\alpha _{D}\) | 0.446 | 0.094 | 0.098 | 0.450 | 0.100 | 0.121 | 0.479 | 0.199 | 0.319 |
\(\delta {A}\) | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.000 | 0.001 |
\(\delta {B}\) | 0.007 | 0.007 | 0.007 | 0.007 | 0.007 | 0.007 | 0.008 | 0.007 | 0.007 |
\(\delta {C}\) | 0.004 | 0.004 | 0.004 | 0.004 | 0.004 | 0.004 | 0.004 | 0.005 | 0.005 |
\(\delta {D}\) | 0.002 | 0.002 | 0.002 | 0.002 | 0.002 | 0.002 | 0.002 | 0.003 | 0.004 |
\(\delta _{A\rightarrow B}\) | 0.129 | 0.130 | 0.130 | 0.129 | 0.130 | 0.133 | 0.127 | 0.126 | 0.110 |
\(\delta _{A\rightarrow C}\) | 0.149 | 0.150 | 0.148 | 0.148 | 0.149 | 0.151 | 0.154 | 0.155 | 0.153 |
\(\delta _{C\rightarrow D}\) | 0.081 | 0.079 | 0.079 | 0.079 | 0.080 | 0.078 | 0.082 | 0.079 | 0.058 |