Table 4 Parameter estimated for the proposed mixed-effects model: Fixed-effects (\(\pmb {\theta }\)) and variance (\(\tau ^2\)) of the random-effects for both the duplication \(\alpha\) and death \(\delta\) parameters for each cell lineage and each rhesus macaque
From: A mixed-effects stochastic model reveals clonal dominance in gene therapy safety studies
ZH33 | ZH17 | ZG66 | ||||
|---|---|---|---|---|---|---|
\(\pmb {\theta }\) | \(\tau ^2\) | \(\pmb {\theta }\) | \(\tau ^2\) | \(\pmb {\theta }\) | \(\tau ^2\) | |
\(\alpha _{T}\) | 0.813 | 1.176 | 2.246 | 1.051 | 1.081 | 2.702 |
\(\alpha _{B}\) | 0.193 | 0.597 | 6.503 | 4.648 | 0.055 | 0.876 |
\(\alpha _{NK}\) | 0.758 | 2.253 | 2.435 | 2.364 | 1.095 | 1.943 |
\(\alpha _{G}\) | 0.197 | 0.403 | 10.931 | 53.216 | 0.847 | 1.318 |
\(\alpha _{M}\) | 0.360 | 0.547 | 3.298 | 4.256 | 2.198 | 1.800 |
\(\delta _{T}\) | 0.155 | 0.074 | 0.172 | 0.741 | 0.039 | 0.059 |
\(\delta _{B}\) | 0.102 | 0.059 | 2.159 | 36.268 | 0.006 | 0.051 |
\(\delta _{NK}\) | 0.228 | 0.089 | 0.223 | 0.406 | 0.098 | 0.100 |
\(\delta _{G}\) | 0.039 | 0.029 | 13.211 | 70.756 | 0.018 | 0.017 |
\(\delta _{M}\) | 0.100 | 0.059 | 0.012 | 0.018 | 0.035 | 0.019 |