Table 6 Parameter estimated for the proposed mixed-effects model: Fixed-effects (\(\pmb {\theta }\)) and variance (\(\tau ^2\)) of the random-effects for both the duplication \(\alpha\) and death \(\delta\) parameters for each cell lineage and each treatment group
From: A mixed-effects stochastic model reveals clonal dominance in gene therapy safety studies
PGK | SFV | |||
|---|---|---|---|---|
\(\pmb {\theta }\) | \(\tau ^2\) | \(\pmb {\theta }\) | \(\tau ^2\) | |
\(\alpha _{M}\) | 0.058 | 1.014 | 1.287 | 5.781 |
\(\alpha _{B}\) | 0.092 | 0.872 | 0.024 | 0.408 |
\(\alpha _{T}\) | 0.632 | 2.625 | 3.367 | 2.824 |
\(\delta _{M}\) | 0.095 | 0.041 | 0.232 | 0.085 |
\(\delta _{B}\) | 0.079 | 0.028 | 0.156 | 0.080 |
\(\delta _{T}\) | 0.127 | 0.044 | 0.437 | 0.193 |