Fig. 1

Workflow for the current study, involving extraction of data from L1000 and CMap measured at 10µM and 6 h, in the MCF7 and PC3 cell lines. Compounds were annotated with targets and signatures split into three gene sets based on their identity in the L1000 metadata. Causal reasoning was performed and evaluation metrics computed, on the target- and pathway-levels. Finally, statistical analysis and interpretation of the results were performed