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Table 4 Terms and probabilities (indicating the significance of the effect) for the negative binomial model of number of targets recovered by causal reasoning

From: Benchmarking causal reasoning algorithms for gene expression-based compound mechanism of action analysis

Term

p-value

NetworkMetabase_High

1.87e-11

NetworkMetabase_Med

2.27e-10

NetworkOmnipath

< 2e-16

AlgorithmCausalR_Network

< 2e-16

AlgorithmCausalR_RT

< 2e-16

AlgorithmSigNet

< 2e-16

PlatformLINCS

0.248235

Gene_SetBING

0.295338

Gene_SetLM

3.06e-06

Cell_LinePC3

0.007366

NetworkMetabase_High:AlgorithmCausalR_Network

4.38e-13

NetworkMetabase_Med:AlgorithmCausalR_Network

1.85e-12

NetworkOmnipath:AlgorithmCausalR_Network

< 2e-16

NetworkMetabase_High:AlgorithmCausalR_RT

7.15e-13

NetworkMetabase_Med:AlgorithmCausalR_RT

1.46e-08

NetworkOmnipath:AlgorithmCausalR_RT

< 2e-16

NetworkMetabase_High:AlgorithmSigNet

3.77e-08

NetworkMetabase_Med:AlgorithmSigNet

1.32e-07

NetworkOmnipath:AlgorithmSigNet

< 2e-16

PlatformLINCS: Gene_SetBING

0.321868

PlatformLINCS: Gene_SetLM

0.000346