Table 6 Assimilation of four lemmas to form the alternative theorem of biogenesis of exonic circular RNA
Lemma serial no. | 1 | 2 | 3 | 4 |
|---|---|---|---|---|
Extracts from Lemmas | lncRNA is possible precursor of circular RNA | Some of the RBPs common to both lncRNAs (A) and circular RNAs served as catalyst for circularization of lncRNA | Circularization of lncRNA is mediated by RBP type A both at nucleus and cytosol | Splicing machinery is abundant in cytoplasm and tRNA circularization happens in cytoplasm |
Theorem | Biogenesis of exonic circular RNA is mostly post-transcriptional event which starts with the binding of RBPs common to both lncRNAs and circular RNAs with precursor molecule lncRNAs with some fraction within nucleus and also some within cytosol with exceptions following spatio-molecular arrangements of lncRNA, circular RNA and all types of RBPs | |||