Fig. 2
From: Nfinder: automatic inference of cell neighborhood in 2D and 3D using nuclear markers
Characterization of the neighboring cells network. a Nuclei (red) are connected by solid edges representing cell membrane physical contact. Edge (i, j) is characterized by nucleus-nucleus distance \(r_{ij}\) and the maximum angle subtended with nearby nuclei \(\Theta_{ij}\). b Small-angle limit, showing i and j close together while k is far away. As a result of this, (i, j) are neighbors and k is isolated from both i and j, which is indicated by dashed edges. c Large-angle limit, in which k is potentially blocking the connection between i and j