Fig. 2

Comparison of GWAS results on Crohn´s disease from UK biobank (CD UKBB) and FinnGen (CD FinnGen). Association results on Crohn’s disease from UK biobank A are displayed on a Manhattan plot in orange with lead variants (p < 5 × 10⁻⁸) annotated with their nearest gene. Crohn’s disease association results from FinnGen B are shown in turquoise with lead variants annotated with their nearest genes. An effectplot C showing the effect sizes of the top variants in the CD UKBB dataset against the corresponding effect sizes in the CD FinnGen dataset. The effect sizes of the variants are represented by filled circles and labelled in black if the corresponding p-value for the variant in the second dataset (CD UKBB) is below (p < 5 × 10⁻⁸), otherwise an un-filled circle is displayed, and the gene label is shown in grey. The effectplot D showing the effect sizes of the top variants in the CD FinnGen dataset compared to the effect sizes of the same variants in the CD UKBB dataset. A snpset E created in topr using the get_snpset function, to extract lead variants from the CD UKBB dataset and matching them with overlapping variants in the CD FinnGen dataset. Simultaneous and overlapping display F of the two Crohn’s disease datasets are shown in (A) and (B). Simultaneous and nonoverlapping display (G) of the two datasets