Fig. 2

Enrichment score distribution (y-axis) for peaks retained by both MSPC and IDR (i.e., common peaks; cyan boxes) and rescued by MSPC but discarded by IDR (i.e., MSPC-specific peaks set; yellow boxes), aggregated by 48 ENCODE TFs in K562 cell line (x-axis). Note that there were no peaks retained by IDR and discarded by MSPC (i.e., MSPC always included IDR results). Among the 48 TFs analyzed, 44 showed higher median genomic annotation enrichments for MSPC-specific peaks (yellow boxes). The remaining 4/48 TFs (MYC, NRF1, THRAP3, and TRIP13) showed significant enrichment in genomic annotations (yellow boxes), although not higher than common peaks (cyan boxes). Note that a few outliers with enrichment scores greater than 8000 are included in the plot