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Fig. 2 | BMC Bioinformatics

Fig. 2

From: eSPRESSO: topological clustering of single-cell transcriptomics data to reveal informative genes for spatio–temporal architectures of cells

Fig. 2

Examples of eSPRESSO analysis in mouse liver lobule a–d and PCW 9 human developmental heart e–h. a, e Graph representation of topology of cells or tissues and a topological distance map of cells for the original (lower left) and resultant (upper right) clusters. We adopted sparse network topology for human developmental heart because of uncertainty. b, f 3D reconstruction of cells with SDGs using UMAP. c, g Gene expression heatmap for the optimized SDGs. d, h GO mapping of SDGs in Biological Process. The p-values determined by hypergeometric distribution statistics are shown on top of bars

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BMC Bioinformatics

ISSN: 1471-2105

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