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Fig. 4 | BMC Bioinformatics

Fig. 4

From: eSPRESSO: topological clustering of single-cell transcriptomics data to reveal informative genes for spatio–temporal architectures of cells

Fig. 4

Application of eSPRESSO to detect temporal discriminator genes (TDGs) in human developmental pancreas. a Graph representation of cell type differentiation model and a topological distance map of cells for the original (lower left) and resultant (upper right) clusters. b 3D temporal reconstruction of cells with TDGs using UMAP for cell types. c Gene expression heatmap for the optimized TDGs. d GO mapping of TDGs in Biological Process. The p-values determined by hypergeometric distribution statistics are shown on top of bars. e Derived differentiation relationships of cell types from b by graphical lasso based on covariances of gene expressions among cell types. f Gene expression gradients in reconstructed temporal structure for the top three most important genes in VKO analysis

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BMC Bioinformatics

ISSN: 1471-2105

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