Fig. 3

The strongest interactions are positive and occur between genes that are physically close together. However, strong interactions still occur between genes that are far apart. The horizontal axis is the shortest-path graph distance between a pair of genes in a pangenome graph, and the vertical axis is the coevolution score between those genes. The blue points indicate pairs that have score > 25 and a graph distance > 30 (the vertical dotted line), and the orange points indicate pairs that have score > 60 and graph distance < 30. All points with scores less than 15 were removed