Fig. 4

Mutations in the KRAS protein. A The G12V mutation (WT, left; G12V, right). The SIFT score is zero and the prediction is ‘deleterious_low_confidence’. The active site magnesium ion (green sphere) and nonhydrolyzable ATP analog GNP are seen near the mutated residue. B The D154N mutation (WT, left; D154N, right). The SIFT score is zero and the prediction is ‘deleterious_low_confidence’. The red arrows highlight the hydrogen bond to a water molecule that is removed by the mutation