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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Beyond the state of the art of reverse vaccinology: predicting vaccine efficacy with the universal immune system simulator for influenza

Fig. 1

Workflow of the proposed advanced RV pipeline for multi-epitope vaccine design. After retrieving the H5N1 strain sequence from the NCBI database and performing Multiple Sequence Alignment (MSA), we predict CTL, Helper T-lymphocyte, and B cell epitopes using specific bioinformatic tools to evaluate their antigenicity and allergenicity levels and select the best epitopes. Finally, UISS-FLU is run to predict the efficacy of the multi-epitope vaccine formulation

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BMC Bioinformatics

ISSN: 1471-2105

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