Beyond the state of the art of reverse vaccinology: predicting vaccine efficacy with the universal immune system simulator for influenza

Table 1 Selected CD8, CD4 and B cell epitopes accordingly to the score computed by NetCTL, NetMHCIIpan and BepiPred predictors

ID	Allele	Epitope	Antigenicity	Allergenicity	Score
MHC-I (CD8 T cells)
CTL1	HLA-A*01:01	KSDQICIGY	Antigenic	Non-allergen	0,889,895
CTL2	HLA-A*24:02	LYDKVRLQL	Antigenic	Non-allergen	0,736,697
CTL3	HLA-B*07:02	CPYQGKSSF	Antigenic	Allergen	0,917,161
MHC-II (CD4 T cells)
HTL1	DRB1_0101	EWSYIVEKANPANDL	Antigenic	Non-allergen	0.994155
HTL2	DRB1_0101	SYIVEKANPANDLCY	Antigenic	Non-allergen	0.877016
HTL3	DRB1_0101	PTTYISVGTSTLNQR	Antigenic	Non-allergen	0.793413
HTL4	DRB1_0101	EFFWTILKPNDAINF	Antigenic	Non-allergen	0.862769
HTL5	DRB1_0402	KIQIIPKSSWSSHEA	Antigenic	Non-allergen	0.834586
HTL6	DRB1_0402	IQIIPKSSWSSHEAS	Antigenic	Non-allergen	0.642752
HTL7	HLA-DPA10401-DPB10401	GRMEFFWTILKPNDA	Antigenic	Non-allergen	0.26179
HTL8	HLA-DPA10401-DPB10401	RMEFFWTILKPNDAI	Antigenic	Non-allergen	0.25399
HTL9	DRB1_0101	PEWSYIVEKANPAND	Antigenic	Non-allergen	0.995068
HTL10	HLA-DPA10401-DPB10401	GRMEFFWTILKPNDA	Antigenic	Non-allergen	0.261798
HTL11		DAINFESNGNFIAPE	Antigenic	Non-allergen	0.58238

ID	Epitope	Antigenicity	Allergenicity	Score
B_HA
B_HA1	QRLVPRIATRSKVNGQSG	Antigenic	Non-allergen	0.569
B_HA2	GAINSSMPFHNI	Antigenic	Non-allergen	0.582
B_HA3	MESVRNGTYDYPQYSEEARLKREEI	Antigenic	Non-allergen	0.5354
B_NA
B_NA1	DTVGWSWPDGAELPF	Antigenic	Non-allergen	0.53013333
B_NA2	LLNDKHSNGTVKDRSP	ANTIGEN	Allergen	0.637

Antigenicity and allergenicity was also evaluated through VaxiJen and AllerTOP servers

ISSN: 1471-2105