Table 3 Quick view of sources for statistical analysis of metabolomics data
From: Statistical methods and resources for biomarker discovery using metabolomics
MetaboAnalyst 5.0/MetaboAnalystR | Mzmine 3 | Metabolyzer | PhenoMeNal | SECIMTools | Umetrics SIMCA | XCMS online / XCMS | MAIT | Omu (count data) | Specmine | pmartR | muma | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Platforms | W/R | W | W | W | W | A | W/R | R | R | R | R | R |
Ref | [56] | [57] | [58] | [59] | [60] | [61] | [62] | [63] | [64] | [65] | [66] | [67] |
Pre-processing | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |||
Imputation | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||||
Filtering | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |||||
Normalization | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
Univariate | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
Multivariate | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
ROC analysis | ✓ | ✓ | ✓ | - | ✓ | ✓ | ✓* | ✓* | ✓* | ✓* |