Fast and accurate genome-wide predictions and structural modeling of protein–protein interactions using Galaxy

BMC Bioinformatics

Table 3 shows sites on DPP4 that are critical in binding MERS-CoV’s receptor-binding domain (RBD) and sites predicted to interact with SARS-CoV2’s RBD

Sites on DPP4	Interacting virus	Critical, polymorphic or novel
K267	MERS-CoV	Critical and Polymorphic
R317	MERS-CoV	Critical and Polymorphic
R336	MERS-CoV	Critical
Q344	MERS-CoV	Critical
T186	SARS-CoV2	Novel
T282	SARS-CoV2	Novel
S334	SARS-CoV2	Novel

Sites on DPP4 that are known to be polymorphic in the Human population are highlighted. The results indicate that SARS-CoV2 interacts with sites on DPP4 known to be critical and additional novel sites

ISSN: 1471-2105