Fig. 7

Multidimensional analysis between KLF2 expression and immune microenvironment in HCC. A KLF2 expression positively correlated with stromal score, immune score, and ESTIMATE score in HCC. B KLF2 expression is significantly positively related to infiltrating levels of CD4⁺ T cells, CD8⁺ T cells, B cells, dendritic cells, macrophages, and neutrophils in HCC. C Heat map of the correlation between the expression of KLF2 and immune-checkpoint-related genes. The different colors represent the trend of gene expression in different samples. D Correlation analysis between KLF2 gene expression and TMB. E, F Scatter plots show KLF2 expression is associated with PDCD1 and CD274. G, H Comparison of response to ICB treatments in KLF2 high- and low-expression groups. I, J Prognostic KM curves of high- and low-expression groups of KLF2. *P < 0.05, **P < 0.01, ***P < 0.001