Fig. 3
From: PATH-SURVEYOR: pathway level survival enquiry for immuno-oncology and drug repurposing
Gene-set Enrichment Analysis with Genes Ranked by Hazard Ratio. A Genes can be ranked based on the hazard ratio for overall survival (OS). GSEA can be applied to examine for similarity in gene features that are shared in high or low-risk diseases. Interferon Gamma (B), the LCK Signature (C), and the Cytotoxic signature (D) were found to be associated with low-risk patients based on GSEA. Kaplan Meier curves showing patients dichotomized based on ssGSEA immune signatures are shown on the right in skin cancer patients treated with ICI and validated in a separate cohort of patients treated with ipi adjuvant therapy