Table 5 Top-25 ranked novel DTIs predicted on the GPCR data set by MOKPE
Drug ID | Drug name | Target ID | Target name | Validation source |
|---|---|---|---|---|
Data Set: GPCR (R=2) | ||||
D01692 | Alfuzosin hydrochloride | hsa152 | ADRA2C (Adrenoceptor Alpha 2C) | None |
D00613 | Fenoldopam mesylate | hsa11255 | HRH3 (Histamine Receptor H3) | None |
D00613 | Fenoldopam mesylate | hsa59340 | HRH4 (Histamine Receptor H4) | None |
D00965 | Nilutamide | hsa152 | ADRA2C (Adrenoceptor Alpha 2C) | None |
D04375 | Guanabenz | hsa152 | ADRA2C (Adrenoceptor Alpha 2C) | KEGG & GtP |
D00318 | Famotidine | hsa152 | ADRA2C (Adrenoceptor Alpha 2C) | None |
D00380 | Tolbutamide | hsa134 | ADORA1 (Adenosine A1 Receptor) | None |
D00514 | Dexmedetomidine | hsa152 | ADRA2C (Adrenoceptor Alpha 2C) | KEGG & GtP |
D02327 | Doxylamine succinate | hsa1131 | CHRM3 (Cholinergic Receptor Muscarinic 3) | None |
D02234 | Cyproheptadine hydrochloride | hsa11255 | HRH3 (Histamine Receptor H3) | None |
D02327 | Doxylamine succinate | hsa1133 | CHRM5 (Cholinergic Receptor Muscarinic 5) | None |
D02340 | Loxapine | hsa1129 | CHRM2 (Cholinergic Receptor Muscarinic 2) | DRUGBANK |
D01965 | Silodosin | hsa152 | ADRA2C (Adrenoceptor Alpha 2C) | None |
D01973 | Eletriptan hydrobromide | hsa3356 | HTR2A (5-Hydroxytryptamine Receptor 2A) | None |
D00079 | Dinoprostone | hsa5731 | PTGER1 (Prostaglandin E Receptor 1) | DRUGBANK & DTC & CTD & GtP |
D02357 | Methysergide | hsa3360 | HTR4 (5-Hydroxytryptamine Receptor 4) | None |
D02340 | Loxapine | hsa1128 | CHRM1 (Cholinergic Receptor Muscarinic 1) | DRUGBANK |
D02349 | Dipivefrin | hsa3274 | HRH2 (Histamine Receptor H2) | None |
D02327 | Doxylamine succinate | hsa1132 | CHRM4 (Cholinergic Receptor Muscarinic 4) | None |
D01020 | Methoxamine hydrochloride | hsa152 | ADRA2C (Adrenoceptor Alpha 2C) | None |
D00437 | Nifedipine | hsa3274 | HRH2 (Histamine Receptor H2) | None |
D02349 | Dipivefrin | hsa152 | ADRA2C (Adrenoceptor Alpha 2C) | KEGG |
D02327 | Doxylamine succinate | hsa1814 | DRD3 (Dopamine Receptor D3) | None |
D01164 | Aripiprazole | hsa1129 | CHRM2 (Cholinergic Receptor Muscarinic 2) | DRUGBANK |
D01297 | Pirenzepine hydrochloride | hsa1131 | CHRM3 (Cholinergic Receptor Muscarinic 3) | KEGG |