Table 6 Top-25 ranked novel DTIs predicted on the IC data set by MOKPE
Drug ID | Drug name | Target ID | Target name | Validation source |
|---|---|---|---|---|
Data Set: IC (R=10) | ||||
D00349 | Isradipine | hsa773 | CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A) | None |
D00349 | Isradipine | hsa777 | CACNA1E (Calcium Voltage-Gated Channel Subunit Alpha1 E) | CTD |
D00638 | Flecainide acetate | hsa8645 | KCNK5 (Potassium Two Pore Domain Channel Subfamily K Member 5) | None |
D00349 | Isradipine | hsa774 | CACNA1B (Calcium Voltage-Gated Channel Subunit Alpha1 B) | None |
D03991 | Encainide hydrochloride | hsa8645 | KCNK5 (Potassium Two Pore Domain Channel Subfamily K Member 5) | None |
D00349 | Isradipine | hsa5310 | PKD1 (Polycystin 1, Transient Receptor Potential Channel Interacting) | None |
D00438 | Nimodipine | hsa773 | CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A) | None |
D00619 | Verapamil hydrochloride | hsa3739 | KCNA4 (Potassium Voltage-Gated Channel Subfamily A Member 4) | None |
D03365 | Nicotine | hsa1137 | CHRNA4 (Cholinergic Receptor Nicotinic Alpha 4 Subunit) | KEGG & DRUGBANK & DTC & GtP |
D00438 | Nimodipine | hsa781 | CACNA2D1 (Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1) | None |
D00349 | Isradipine | hsa782 | CACNB1 (Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1) | None |
D00438 | Nimodipine | hsa779 | CACNA1S (Calcium Voltage-Gated Channel Subunit Alpha1 S) | KEGG & DRUGBANK & GtP |
D05024 | Mibefradil dihydrochloride | hsa5310 | PKD1 (Polycystin 1, Transient Receptor Potential Channel Interacting) | None |
D05024 | Mibefradil dihydrochloride | hsa774 | CACNA1B (Calcium Voltage-Gated Channel Subunit Alpha1 B) | None |
D00647 | Dofetilide | hsa9424 | KCNK6 (Potassium Two Pore Domain Channel Subfamily K Member 6) | None |
D00364 | Loratadine | hsa3737 | KCNA2 (Potassium Voltage-Gated Channel Subfamily A Member 2) | None |
D00615 | Amlodipine besylate | hsa774 | CACNA1B (Calcium Voltage-Gated Channel Subunit Alpha1 B) | None |
D00640 | Propafenone hydrochloride | hsa3743 | KCNA7 (Potassium Voltage-Gated Channel Subfamily A Member 7) | None |
D00619 | Verapamil hydrochloride | hsa3741 | KCNA5 (Potassium Voltage-Gated Channel Subfamily A Member 5) | None |
D00616 | Diltiazem hydrochloride | hsa3739 | KCNA4 (Potassium Voltage-Gated Channel Subfamily A Member 4) | None |
D01969 | Gallopamil hydrochloride | hsa778 | CACNA1F (Calcium Voltage-Gated Channel Subunit Alpha1 F) | KEGG |
D00364 | Loratadine | hsa3746 | KCNC1 (Potassium Voltage-Gated Channel Subfamily C Member 1) | None |
D00619 | Verapamil hydrochloride | hsa3746 | KCNC1 (Potassium Voltage-Gated Channel Subfamily C Member 1) | None |
D00647 | Dofetilide | hsa3756 | KCNH1 (Potassium Voltage-Gated Channel Subfamily H Member 1) | GtP |
D00619 | Verapamil hydrochloride | hsa3737 | KCNA2 (Potassium Voltage-Gated Channel Subfamily A Member 2) | None |