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Fig. 6 | BMC Bioinformatics

Fig. 6

From: MAVEN: compound mechanism of action analysis and visualisation using transcriptomics and compound structure data in R/Shiny

Fig. 6

DoRothEA results derived from the differential expression signature of lapatinib-treated HER2 + BT474 cells expressed as a colour-coded bar plot. NES = Normalised enrichment score. Here, the most enriched upregulated TF (indicated by a positive NES) was FOXO3, and the most enriched downregulated TF (indicated by a negative NES) was ESRRA, which matches with the known activity of lapatinib in HER2 + cells

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BMC Bioinformatics

ISSN: 1471-2105

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