Fig. 4
From: ROGUE: an R Shiny app for RNA sequencing analysis and biomarker discovery
Using differentially expressed pathways to generate and/or explore hypotheses. A Distribution of MDA-5 signaling pathway in untreated (red) and IFNβ-treated (blue) CD4+ T cells showing an upregulation of genes related to MDA-5 signaling. B, C Distribution of 2′–5′-oligoadenylate synthetase activity in untreated (red) and IFNβ-treated (blue) CD8+ T cells (B) and NK cells (C) showing an upregulation of genes 2′–5′-oligoadenylate synthetase activity. D Boxplots showing pathways that may be differentially regulated in neutrophils with multiple genes consistently upregulated or downregulated post-IFNβ treatment. E Bar plot showing upregulated MDA-5 (IFIH1), RIG-I (DDX58), and genes related to 2′–5′-oligoadenylate synthetase in IFNβ-treated monocytes, neutrophils, CD4 + T cells, CD8 + T cells, and NK cells