Fig. 11
From: Molecular complex detection in protein interaction networks through reinforcement learning
Structural modeling supports C15orf41, CDAN1, ASF1A, and HIRA participating in a large multiprotein complex. Using AlphaFold-multimer, we find that all four proteins can be simultaneously accommodated within a single multiprotein complex, here showing C15orf41’s modeled interaction with CDAN1 residues 2–74 and 286–1203, ASF1A residues 1–155, and HIRA residues 421–479. For illustration purposes, the known crystal structure of HIRA 446–466 [56] has been superimposed onto the AlphaFold model, which is available in full from the supporting GitHub repository with accompanying quality measurements