VariantscanR: an R-package as a clinical tool for variant filtering of known phenotype-associated variants in domestic animals

Table 2 Breeding advice for phenotype-associated non-reference variants that occur in a homozygous state

Inheritance pattern	Breeding advice
Autosomal dominant	Animal can NOT be used for breeding purposes. Offspring would be carrier or homozygous and might develop symptoms
Autosomal recessive	ONLY combine with wild type animal! Offspring will be carrier and, on its turn, can ONLY be combined with wild type animal ***
Mitochondrial	If animal is female: animal can NOT be used for breeding purposes. Mitochondria are inherited maternally
X linked dominant	Do NOT use animal for breeding purposes because all offspring will inherit the defective X chromosome
X linked recessive	Do NOT use animal for breeding purposes as all male offspring will inherit the defective X chromosome and will thus be affected
NA	Not able to provide breeding advice because inheritance pattern was not included in the input file

***Important general side note: Do NOT use animal if this would harm the welfare of the animal itself, or the progeny. Furthermore, the animal must be capable of carrying out a healthy pregnancy

ISSN: 1471-2105