Table 3 Breeding advice for phenotype-associated non-reference variants that are found to be heterozygous
Inheritance pattern | Breeding advice |
|---|---|
Autosomal dominant | Animal can NOT be used for breeding purposes |
Autosomal recessive | Animal can be used for breeding purposes but ONLY if combined with a wild type animal. Offspring will be ± 50% carrier and ± 50% wild type |
Mitochondrial* | If animal is female: animal can NOT be used for breeding purposes. Mitochondria are inherited maternally. If animal is male: animal can be used |
X linked dominant | If animal is female: do NOT use animal for breeding purposes because ± 50% of the offspring will inherit the defective X chromosome |
| Â | If animal is male, only one X chromosome is present. Accordingly, affected animals can NOT be used for breeding purposes as all female offspring will be carrier and thus will be affected |
X linked recessive | If animal is female: animal can NOT be used for breeding purposes as ± 50% of male offspring will inherit the defective X chromosome and these male animals will develop symptoms |
| Â | If animal is male, only one X chromosome will be present. Affected animals can be used ONLY if combined with a wild type female animal. Female offspring will be carrier of the variant |
Y linked | The animal is male and can NOT be used for breeding purposes as every male offspring will inherit the defective Y chromosome |
NA | Not able to provide breeding advice because inheritance pattern was not included in the input file |