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Table 3 MajS and Iggy predictions upon perturbations of HIF1A for 3 Benchmarks

From: Predicting weighted unobserved nodes in a regulatory network using answer set programming

 

HIF1A\(=\)

HIF1A\(=\)0

HIF1A\(= +\)

Name

MajS

Iggy

MajS

Iggy

MajS

Iggy

ALDOA

(0,100)

Na

(\(+\),25)

\(+\)

(\(+\),50)

\(+\)

ENO1

(0,100)

Na

(\(+\),25)

\(+\)

(\(+\),50)

\(+\)

ENO2

(0,100)

Na

(\(+\),25)

\(+\)

(\(+\),50)

\(+\)

ENO3

(0,100)

Na

(\(+\),25)

\(+\)

(\(+\),50)

\(+\)

GAPDH

(0,100)

Na

(\(+\),25)

\(+\)

(\(+\),50)

\(+\)

HK1

(0,100)

Na

(\(+\),25)

\(+\)

(\(+\),50)

\(+\)

HK2

(0,100)

Na

(\(+\),25)

\(+\)

(\(+\),50)

\(+\)

HK3

(0,100)

Na

(\(+\),25)

\(+\)

(\(+\),50)

\(+\)

LDHA

(0,100)

Na

(\(+\),25)

\(+\)

(\(+\),50)

\(+\)

PFKL

(0,100)

Na

(\(+\),25)

\(+\)

(\(+\),50)

\(+\)

PGK1

(0,100)

Na

(\(+\),25)

\(+\)

(\(+\),50)

\(+\)

SLC2A1

(0,100)

Na

(\(+\),25)

\(+\)

(\(+\),50)

\(+\)

PDHA1

(0,100)

Na

\((-,100)\)

\((-,100)\)

PDHA2

(0,100)

Na

\((-,100)\)

\((-,100)\)

PDHB

(0,100)

Na

\((-,100)\)

\((-,100)\)

  1. \(Benchmark\_minus\) contained HIF1A=“–”; \(Benchmark\_zero\) contained HIF1A=“0” and \(Benchmark\_plus\) contained HIF1A=“+”. Here, “Na” means that Iggy could not predict for this Benchmark. MajS gives a predicted node as a tuple composed of the majoritarian sign and its average weight; the standard deviation is 0. The colours are focused on Benchmark_zero and Benchmark_plus; the enzymes predicted with “+” sign appear in bold. The ones predicted with “–” appear in italics