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Table 4 Results of the various validation methods applied to the L858R subset. (PH = proportional hazards)

From: Empirical methods for the validation of time-to-event mathematical models taking into account uncertainty and variability: application to EGFR + lung adenocarcinoma

Method

Metric value (%)

Ratio of of samples where PH assumption is not met (%)

Raw coverage

99.62

NA

Juncture

99.62

NA

Bootstrapped LR (no OTU)

97.6

2.38

Bootstrapped LR (with OTU)

98.94

5.32

Bootstrapped weighted log-rank combo (no OTU)

97.14

2.8

Bootstrapped weighted log-rank combo (with OTU)

98.94

5.7