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Table 5 Differences between the results obtained on the initial dataset and the Del19 and L858R subsets

From: Empirical methods for the validation of time-to-event mathematical models taking into account uncertainty and variability: application to EGFR + lung adenocarcinoma

Method

Difference between full dataset and Del19

Difference between full dataset and L858R

Difference between Del19 and L858R datasets

Raw coverage

 + 12.02%

 + 41.66%

 + 29.64%

Juncture

− 7.12%

 + 11.91%

 + 19.03%

Bootstrapped LR (no OTU)

− 3.66%

 + 9.74%

 + 13.4%

Bootstrapped LR (with OTU)

− 3.88%

 + 0.8%

 + 4.68%

Bootstrapped weighted log-rank combo (no OTU)

+ 6.2%

 + 36.24%

 + 32.24%

Bootstrapped weighted log-rank combo (with OTU)

− 3.22%

 + 11.7%

 + 14.92%