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Fig. 1 | BMC Bioinformatics

Fig. 1

From: scSNPdemux: a sensitive demultiplexing pipeline using single nucleotide polymorphisms for improved pooled single-cell RNA sequencing analysis

Fig. 1

a Description of the scSNPdemux workflow. b A barplot summarizing the number of assigned cells independently by CellPlex and scSNPdemux. c The sensitivity and specificity estimation by copy number defined tumour clusters, assuming tumour cells from different patients share a similar copy number profile and form distinct clusters on transcriptome level. d The comparison between CellPlex and scSNPdemux by overlaying the demultiplexed cell labels onto the UMAP. e Comparison of demultiplexing a mixture of Jurkat, HEK293 and HMEC cells by Multi-seq and scSNPdemux. T-SNE map showing three cell types and barplots presenting the fraction of cells assigned. (1) Huang and Huang [2], (2) Huang et al. [3]

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BMC Bioinformatics

ISSN: 1471-2105

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